Plasma Lipid Profiles of leukemia Patients

Irregularities in the plasma lipid profiles of leukemia patients have also been widely observed. Most of the previous reports have demonstrated decrease in total cholesterol (TC) and various lipoprotein sub-fractions particularly, high-density lipoprotein cholesterol (HDL-C). Whereas, increase in the serum triglyceride (TG) levels of the leukemia patients is also a frequently observed phenomenon. Nevertheless there are several inconsistencies in the previous reports. The fact that, most of these works overlooked the effects of various confounding factors and comorbidities has been suggested to be the major cause for these discrepancies in the literature.  In “Cancer Research Lab, MMG” we are not only revisiting the abnormalities in plasma lipid profiles of leukemia patients but we are also trying to decipher the underlying mechanisms modulating these abnormalities. We studied the impact of various confounding risk factors on plasma lipid levels in leukemia patients. We observed that patients with acute lymphocytic leukemia (ALL) display elevated levels of TG and VLDL-C when compared to the healthy subjects. Gender-based analysis revealed that this elevation in TG and VLDL-C levels was restricted to female participants of the ALL population. Age- and BMI-based analysis also revealed certain differences that were masked in the overall analysis.The types of mixed dyslipidemia that were observed to be significantly increased in ALL patients were; high triglyceride and VLDL-C levels.

Prevalence of atherogenic and leukemia associated lipid triad in healthy subjects, ALL and AML patients. Significance was determined by applying z-test for two population proportions. * p-values<0.05 were considered statistically significant.

Related Publications from Our Lab

  1. Iqbal A, Zaid M, Munir R, Usman H, Kalbacher H, Scandiuzzi L, Zaidi N:Atypical plasma lipid profiles in leukemia.Clin Chim Acta 2016, 452:129-133.
  2. Usman H, Rashid R, Ameer F, Iqbal A, Zaid M, Hasnain S, Kalbacher H, Zaidi N: Revisiting the dyslipidemia associated with acute leukemia.Clin Chim Acta 2015, 444:43-49.
  3. Rashid R, Ameer F, Kalbacher H, Scandiuzzi L, Zaidi N: Aberrant de novo cholesterogenesis: Clinical significance and implications.Clin Chim Acta
  4. Munir R, Usman H, Hasnain S, Smans K, Kalbacher H, Zaidi N: Atypical plasma lipid profile in cancer patients: cause or consequence?Biochimie 2014, 102:9-18.

Related Theses from Our Lab

LevelStudent’s NameThesis TitleYear
PhDHina UsmanRegulation of plasma and cellular cholesterol levels in acute myeloid and lymphocytic leukemiaSubmitted in 2019
M.Phil./M.SAreeb IqbalCholesterol Homeostasis in Acute Leukaemia Patients: Studying the Intra- and Extracellular Cholesterol Content2014-15
Rida RashidLipoproteins and lipoprotein ratios: studying anomalies and correlations in cancer patients.2013-14
Fatima AmeerMetabolic profiles of haematological cancer patients revisited: studying the irregularities and interdependencies of plasma glucose and lipid levels2013-14
Rimsha MunirBlood lipid profiles in cancer patients- site specific analysis2012-13
Undergraduate Komal SaleemAcute Myeloid Leukemia: Metabolic Alterations in the Peripheral Blood Environment and Intracellular Cholesterol Reservoirs2014-15
Hafsa AnwarAcute Lymphocytic Leukemia: Metabolic Alterations in the Peripheral Blood Environment and Intracellular Cholesterol Reservoirs2014-15
Komal EjazPlasma glucose levels and cancer: revisiting the differences between control and cancer populations2013-14
Rabbia TariqPlasma lipids and lipoproteins in haematological malignancies: revisiting the differences between control subjects and cancer patients2013-14
Asma KalsoomPlasma lipids and lipoproteins in gynaecological malignancies: revisiting the differences between control subjects and cancer patients2013-14
M. Jaffer HussainAberrant plasma cholesterol profile in cancer patients2012-13